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The term melasma derives from the Greek word for black, referring to its distinctive dark appearance that resembles cooked liverthough it has no connection to liver dysfunction

165 Saunders-PullmanR.Gordon-ElliottJ.ParidesM.FahnS.SaundersH

J Am Acad Dermatol 37(4):575577

To further interrogate the specific pathways involved in the altered biological functions in metformin treated SW837 cells, Canonical Pathway Analysis was also performed on differentially expressed genes using IPA software