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Bile acids (BAs) play a crucial role as detergents in lipid digestion and are known to exhibit abnormal metabolic patterns in individuals with NAFLD (281)

The gut microbiome generates short-chain fatty acids, and butyrate in particular, from precursors such as lactate, succinate, certain amino acids, and carbohydrates (164167)

Additionally, studies in mice have shown higher liver and kidney expression of Selenop in females than that in males (Schomburg et al., 2007), so SELENOP/LRP8-brain Se uptake pathway may also exert sex-dependence

In HGSOC, drug-resistant cells frequently exhibit the overexpression of transporters, resulting in increased drug efflux and decreased intracellular drug concentrations, thereby diminishing drug efficacy