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Theres research dating back to the 1950s looking for a link between vitamin B12 and psoriasis

Vitamin B12, also known as cobalamin , is a water-soluble vitamin, which means it dissolves in water and is not stored in the fat cells

The most frequent is transient injection-site irritation

In patients in the placebo-controlled studies of STS 6 mg/24 hours, the only adverse event with an incidence of twice that of the placebo group was application site reaction.55 In higher-dose studies (9 mg/24 hours or 12 mg/24 hours), adverse events with an incidence of at least twice that of placebo included insomnia (32% vs 7%), dry mouth (13% vs 6%), dizziness (14% vs 5%), nervousness (10% vs 4%), and abnormal dreams (5% vs 2%).55 Most adverse events were considered mild or moderate