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TRP channels are polymodal ion channels that have the role of integrating and transmitting a variety of environmental stimuli, including physical stimuli such as mechanical and thermal, and/or chemical stimuli such as pH and plant-derived compounds

Conversely, cancer stem cells (CSCs) preferentially rely on OXPHOS to meet the bioenergetic demands required for maintaining stemness, thereby contributing to therapeutic resistance and tumor recurrence [68]

In three such high fat diet studies, metformin treatment reduces cognitive deficits ( Table 1 Studies investigating the effect of metformin on neurodegeneration in rodent models